Discodermolide is a recently discovered polyketide natural productfound to be a potent inhibitor of tumor cell growth. The molecule's carbon skeleton is made up of eight polypropionate and four acetate units with 13 stereocenters. Discodermolide was first isolated in 1990 from the Caribbean marine sponge Discodermia dissoluta by chemist Dr. Sarath Gunasekera and biologist Dr. Ross Longley, scientists at the Harbor Branch Oceanographic Institution.The sponge contained 0.002% of discodermolide.Since the compound is light sensitive,the sponge should be harbested at a depth of 33 meters. Discodermolide was first found that the immunosuppressive and antifungal activities.
Discodermolide has been shown to inhibit the proliferation of human cells by arresting the cell cycle in G2- and M-phase. It hyper-stabilizesmicrotubules, especially prevalent during cell division. Discodermolide competes with paclitaxel for microtubule binding, but with higher affinity and is also effective in paclitaxel- and in epothilone-resistant cancer cells.
Discodermolide has been shown to inhibit the proliferation of human cells by arresting the cell cycle in G2- and M-phase. It hyper-stabilizesmicrotubules, especially prevalent during cell division. Discodermolide competes with paclitaxel for microtubule binding, but with higher affinity and is also effective in paclitaxel- and in epothilone-resistant cancer cells.
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From:Sea extracts
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